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A NEW APPROACH TO THE TREATMENT OF THE PERIODONTAL DISEASE WITH STAPHILOCOCCIC VACCINE. A LONGITUDINAL STUDY authors: Teodor Georgescu, Marian-Vladimir Constantinescu, Irina Codita, Desideriu Lacky, Dan Slãvescu Communication for The 6th Meeting of the International Academy of Periodontology SEOUL, COREEA, September 4-5, 1997
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	CLINICAL EXAMINATION BEFORE TREATEMENT *Clinical pictures show:* Gingival color is dark red Periodontal pockets Inflammatory oedema Spontaneous and/or induced bleeding of gingiva Suppurative exudate Tooth mobility Gingival pain

	MORPHOPATHOLOGICAL STUDY BEFORE THE TREATMENT WITH STAPHILOCOCCIC VACCINE The examination of the biopsic fragments collected before the treatement shows: * in the epithelium of mucosae: - various atrophies of the epithelium cells - ulcerations - superficial supurative purulent fibroleukocytary exudate - necroting debris of cells and tissue structures - bacterial colonies and fungi * in chorion: - unequal granulomatous chronic inflammatory infiltrates with hyperemic vessels - microbial colonies - neutrophilic polymorphic nuclear leukocytes - dissociating and disintegrating connective fibres (GÖMÖRI STAINING)



	CLINICAL EXAMINATION AFTER TREATEMENT *Clinical pictures show:* Gingival color changed from dark to red Inflammatory oedema decreased Periodontal pockets were reduced Reduction or dissaparence of spontaneous and/or induced bleeding of gingiva Reduction or disappearence of suppurative exudate Decrease of thooth mobility Progressive reduction until disappearence of gingival pain Remission by cicatrization of marginal epithelium and thickening of gingiva with fibrous aspect

	MORPHOPATHOLOGICAL STUDY AFTER TREATEMENT WITH STAPHILOCOCCIC VACCINE The examination of the biopsic fragments collected after the treatement shows: * in the epithelium of mucosae: - regenerated epithelium with cellular hyperplasia, hyperkeratosis, papilomatous proliferation in chorion - connective axes among papillomatous proliferations - missing bacterial colonies * in chorion: - rare chronic inflammatory infiltrates - dissapereance of granulomatous tissue - missing bacterial and fungi colonies - abundant reticulinic fibres and densely distributed collagenic fibres (GÖMÖRY STAINING)



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