Curiozinul este un produs organoterapeutic care contine hialuronat de zinc 0,2%.

Hialuronatul de zinc stimuleaza activitatea stimuleaza activitatea granulocitelor, macrofagelor si fibroblastilor ca si accelerarea transportului si eliberarii citokinelor si mediatorilor chimici. In plus, imbunatateste fluxul sanguin la nivelul zonei tratate si favorizeaza proliferarea celulelor epiteliale si a fibroblastilor.

Pentru evaluarea eficacitatii terapeutice sigurantei solutiei de hialuronat de zinc in tratamentul ulcerelor gambiene de origine venoasa s-a efectuat un studiu deschis in Clinica I Dermatologica a Spitalului „N. Gh. Lupu".

Au fost inclusi in studiu 10 pacienti cu ulcere de gamba de origine venoasa, cu varste cuprinse intre 31 si 80 de ani, 5 barbati si 5 femei.

Ulcerele au fost tratate cu solutie de hialuronat de zinc de 0,2%, 1 pic./cm, zilnic timp de 8 satamini.

Aspectul leziunilor, modificarile observate in timpul evolutiei clinice au fost documentate prin masuratori, diagrame si fotografii color.

Rata de vindecare (nr. de pacienti vindecati / nr. total de pacienti inclusi in studiu), a fost de 6/10; ceilalti bolnavi prezentand ameliorari notabile in intervalul de studiu iar un bolnav a fost exclus din studii datorita adaugarii suprainfectiei la nivelul leziunii.

Avantajele aplicarii topice a solutiei de hialuronat de zinc pentru pacienti include: usurinta aplicarii (inclusiv autoaplicarea) si o buna toleranta.

In studiul nostru nu au fost semnalate efecte secundare locale sau generale, cu exceptia unei usoare senzatii de usturime cateva minute dupa aplicarea medicamentului.

In concluzie, consideram ca hialuronatul de zinc s-a dovedit a fi o varianta de tratament eficace si in tratamentul ulcerelor de gamba de etiologie venoasa.

Curiozin is an organotherapeutic product that conteins Zinc hialuronat 0,2%.

Its active substance = Zinc hialuronat = stimulates the activity of granulocytes, macrophages and fibroblasts, as well as enhances the transport of released cytokines and clinical mediators.

Further more, it improves blood Fluor within the treated region and promotes the proliferation of epithelial cells and fibroblasts.

In order to asses the clinical efficacy and safety of Zinc hialuronat in venous ulcers, an open study was been performed in Dermatological Clinic I of "N. Gh. Lupu" Hospital.

We have completed an experimental study involving 10 patients with venous leg ulcers, age between 31 and 80 years - 5 males and females.

The ulcers were treated with 1 drop/cm zinc hialuronat once daily during 8 weeks.

Typical lesions and characteristic changes observed during the clinical course were documented through measurements, diagrams and color photographs.

Cure rate was 6/10, the other 3 patients showing considerable improvements during the study and one patient has been excluded because of secondary infection.

The advantages of Zinc hialuronat for patients include the ease of application (including self-treatment) and a good tolerability. No local or general side effects have been noted in our study except slight burning sensation occurring a few minutes after the applications of Zinc hialuronat.

As a conclusion, the Zinc hialuronat has proven extremely effective even in the treatment of venous leg ulcers.