R1. Sarcomul Kaposi forma mediteraneana - studiu clinic, histologic si epidemiologic asupra 433 de cazuri (1969-1998)
De-a lungul unei perioade de 30 ani am studiat 433 cazuri de sarcom Kaposi. Diagnosticul clinic a fost cel de sarcom Kaposi in 318 cazuri (73,46%), in rest aspectul clinic a sugerat si alte afectiuni: botriomicom, melanom, hemangiopericitom, angiom, pseudo-sarcom Kaposi etc. Majoritatea pacientilor au prezentat leziuni nodulare izolate situate pe placi violacee la nivelul dosului mainilor si picioarelor, uneori pe gambe, in special pe fata lor anterioara. Leziuni ulcerate au fost observate in special la picioare (degete si plante), cu aspect de botriomicom. La debut, leziunile au avut localizari variate: membrele inferioare (71,52%), superioare (15%), extremitatea cefalica (7,69%), penis (1,92), trunchi (1,15%), membre inferioare si superioare (1,92%). 3 pacienti intre 20-30 ani, cu leziuni nodulare generalizate au fost depistati HIV pozitiv si incadrati in forma epidemica a sarcomului Kaposi. Cel mai frecvent varsta de instalare a bolii a fost intre 60-70 ani, cu o prevalenta la sexul masculin (78%): sex ratio 3,3/1. Nu s-au notat cazuri familiale. Diagnosticul de certitudine a fost stabilit histologic: proliferare vasculara, extravazare de eritrocite, proliferare vasculara, proliferare de celule fusiforme in jurul capilarelor aplatizate.
R1. Mediteranean Kaposi's Sarcoma - Clinical, Histological and Epidemiological Study Involving 433 Cases (1969-1998)
During a period of 30 years we have studied 433 cases of Kaposi's sarcoma. In 318 cases (73,46%) the clinical diagnosis was Kaposi's sarcoma, in rest the lesions resembling other diseases, too: pyogenic granuloma, melanoma, hemangiopericytoma, angioma, pseudo-Kaposi's sarcoma etc. Most patients presented nodular isolated tumors of the hands and feet, sometimes over the shanks, especially on their anterior part. Ulcerated lesions have been noted mainly on the feet (fingers and plants) with the aspect of pyogenic granuloma. At the onset of the disease the lesions had various sites: lower extremities (71,52%) upper extremities (15%), head (7,69%), penis (1,92%), trunk (1,15%), both lower and upper extremities (1,92%). 3 patients between 20-30 years old, presenting generalized nodular lesions, were detected HIV seropositives, therefore their diagnosis was epidemic Kaposi's sarcoma. Onset was between 60-70 years, with a male prevalence (78%): sex ratio 3,3/1. There was no familial occurence of the disease noted. The diagnosis of Kaposi's sarcoma was established by histological examination: proliferation of capillary vessels, erytrocyte extravasation and spindle cells proliferation surrounding the collapsed capillaries.