Ulcerele venoase reprezinta o afectiune comuna in cazuistica unui serviciu de dermatologie (14,8% din internarile in Clinica Dermatologica Cluj) si 40-80% dintre ele sunt complicatia unei suferinte posttrombotice. Studiul de fata a determinat frecventa mutatiei fV R5060 - a factorului V al coagularii, care determina rezistenta la proteina C activata, la bolnavii cu ulcer venos de gamba comparativ cu un lot de persoane sanatoase. Analiza
s-a efectuat prin PCR si digestie cu enzima de restrictie. Fiecare lot a fost format din 20 de indivizi.

La bolnavii cu ulcer de gamba mutatia a fost prezenta in stare heterozigota in 8 cazuri si in stare homozigota la un pacient, in timp ce la lotul de control ea nu a fost evidentiata. Diferenta dintre rezultatele celor doua loturi este semnificativa statistic (p=0,0088).

Aceste rezultate ne permit ca pe baza acestui studiu preliminar sa afirmam ca mutatia este prezenta in populatia din Romania si ca ea este puternic asociata cu suferinta venoasa cronica posttrombotica si cu complicatia ei redutabila, ulcerul de gamba.

The chronic leg ulcer is a common disease and has been number of the annual pacient population of the Department of Dermatology of Cluj County Hospital Romania. 40-80% of these registered leg ulcer cases are considered to be caused by thrombosis. The aim of our study is to determine the incidence of the fV R5060 mutation causing activated protein C resistance in patients with leg ulcers, in comparison to healthy controls. By PCR and restriction enzyme digestion analysis we have identified the mutation in 20 patients with leg ulcers and 20 controls.

In the patients with leg ulcers, the Leiden mutation was found in 8 heterozygous cases and in one homozygous while none of our controls carried the mutation.

This results allow us to conclude there is a strong correlation between activated protein C resistance and the occurrence of leg ulcers (p=0,0088).