Sunt relatate trei cazuri oncologice care in urma chimioterapiei cu bleomicina au prezentat pigmentari liniare ale trunchiului. In afara bleomicinei, pacientii nu primisera alte antimiotice cunoscute a fi responsabile de hiperpigmentari cutanate precum busulfan, adriamicina, 5 fluoro-uracil sau ciclofosfamida.

Mecanismul acestor hiperpigmentari ca si a distributiei lor nu este cunoscut. Sediul depozitelor pigmentare pare sa fie epidermic.

We present three cases which after treatment with bleomicine for different neoplasm have presented linear pigmentation of the trunk. The patients did not receive another medication known to induce cutaneous pigmentation as busulfan, adriamycine or cyclophosphamide.

The mechanism and pattern of this pigmentation is yet unknown but the place of storage could be on the epidermis layer.