Descrisa in 1916 de Kyrle sub numele de „hiperkeratoza foliculara si parafoliculara in cutem penetrans", boala Kyrle este o dermatoza rara, inclusa in zilele noastre printre dermatozele perforante. In totalitatea sa, acest grup de afectiuni este destul de rar intalnit, putin cunoscut si incomplet inteles d. p. d. v. patogenic.

Pornind de la un caz pesonal de boala Kyrle idiopatica sunt trecute in revista manifestarile clinice tipice, tabloul histopatologic, problemele de diagnostic diferential si posibilitatile terapeutice. Se insista pe diferentierea de formele asa-numite „simptomatice" sau „dobandite" de boala Kyrle sau „boala perforanta dobandita" - care apar la bolnavi cu insuficienta renala cronica si/sau diabet zaharat.

First described by Kyrle in 1916 as "hyperkeratosis follicularis et parafollicularis in cutem penetrans" the disease which now bears his name is a rare disorder, part of the group of perforating dermatoses. This entire group of disorders is uncommon and poorly understood pathogenically.

Starting from a personal case of idiopathic Kyrle's disease we review the typical clinical manifestations, the histological picture, the differential consideration and the therapeutical possibilities. We point in the differentiation from the so-called "symptomatic" or "acquired" Kyrle's disease, or "acquired perforating disease" which appear in patients with chronic renal failure and/or diabetes mellitus.