Psoriazisul este o boala caracterizata printr-un turn-over crescut al epidermului. Necesarul energetic pentru acest proces este obtinut prin metabolizarea glucozei, in special pe calea pentozofosfatilor, implicand participarea glucozo-6-fosfat dehidrogenazei
(G 6 PDH) ca prima enzima a acestui lant metabolic. Inhibitorii G-6-PDH precum antralinul, sunt utilizati cu succes de muti ani in tratamentul acestei boli. Un alt inhibitor al acestei enzime este oxigenul ionic. Noi am obtinut oxigen ionic pentru tratarea psoriazisului cu plagi cronice utilizand peroxidul de benzoil intr-o formula originala. Pe un lot de 22 de bolnavi care s-au oferit voluntar pentru testarea preparatului am obtinut in peste 90% din cazuri albirea leziunilor dupa 3-4 saptamani de tratament. Studii ulterioare vor identifica, probabil, alti inhibitori ai G-6-PDH pentru a fi utilizati in tratamentul psoriazisului.

Psoriasis is a disease characterized by a high turn-over of the epidermis. The amount of energy required by this process comes from the glucose metabolization, especially by pentosophosphats pathway, revealing the participation of the glucose-6-phosphat dehydrogenase (G-6-PDH) as the first enzyme of this metabolic chain, The G-6-PDH inhibitors such as the ditranol have been successfully used for many years in the treatment of this disease. Another inhibitor of this enzyme is the ionic oxygen. We obtained the ionic oxygen for the treatment of the chronic plaques of psoriasis by using the benzoyl peroxide in an original formula. By help of a lot of 22 patients who offered themselves voluntarily for testing our formula, we discovered that in over 90% of the cases, the lesions cleared after 3-4 weeks of treatment. It is possible for the future studies to identify other G-6-PDH inhibitors which should be used in the treatment of psoriasis.