Rezumat. Metilprednisolon aceponat este un nou glucocorticoid sintetic al firmei Schering AG utilizat in tratamentul topic al eczemelor si comercializat sub numele de ADVANTAN-crema, unguent sau unguent gras.

Studiul a urmarit evaluarea eficientei si tolerabilitatii preparatului pentru fiecare forma in parte (crema, unguent sau unguent gras) si comparativ fata de alti glucocorticoizi cum sunt clobetazol propionat, hidrocortizon butirat, triamcinolon acetonid si mometazona furoat si a eficientei comparative a administrarii o data pe zi fata de doua ori pe zi.

Concluzii. Metilprednisolon aceponat (MPA) este un glucocorticoid sintetic cu inalta eficienta in tratamentul eczemelor endogene si exogene, atat la adult cat si la copil. Aplicat o singura data pe zi MPA are aceeasi rata de succes ca si corticoizii de aceeasi potenta aplicati de doua ori pe zi.

Summary. Methylprednisolonum aceponate (ADVANTAN) is a new corticosteroid synthetic developed by Schering AG for external use (cream, ointment or fatty ointment) in the topic treatment of eczema.

The aim of the study was to evaluate the efficiency and tolerance of the product for each form (cream, ointment or fatty ointment) and comparative to other corticosteroids such as: clobetasol propionate, hydrocortisone butirate, triamcynolone acetonide and mometasone furoate and the comparative efficiency in a twice-a day versus once-a day administration.

Conclusion. Methylprednisolonum aceponate is a highly efficient dermatocorticosteroid useful for the treatment of endogenous and exogenous eczema both in adults and children. Applied once-a day it has the same rate of succes like other corticosteroids with the same potency which are applied twice-a day.