Proteina p53 are un rol major in reglarea ciclului celular, respectiv in controlul proliferarii celulare. Mutatia la nivelul acestei proteine este modificarea somatica cea mai comuna gasita in cancerele umane.

Studiul imunohistochimic cu anticorpi monoclonali anti-p53 a fost efectuat comparativ pe 16 cazuri de carcinoame spinocelulare de buza inferioara, 4 cazuri de keratoacantom si 4 cazuri de boala Bowen.

Media celulelor p53 pozitive este semnificativ diferita in leziunile cu potential minim, mediu si maxim de agresivitate. Astfel, in carcinoamele spinocelulare de buza inferioara, media celuleor p53 pozitive este semnificativ crescuta (+41%) fata de celelalte entitati luate in studiu (p<0,005).

Protein p53 plays a major role in the regulation of the cell cycle and in the control of cell proliferation respectively.

The mutation at the level of this protein is the most common somatic modification found in human cancer.

A comparative immunohistochemical study with anti-p53 monoclonal antibodies was performed in 16 cases of squamous cell carcinoma of the lower lip, four cases of keratoacanthoma, and four cases of Bowen's disease. The mean of p53-positive cells was significantly different in lesions with minimal, moderate and maximal aggresive potential. Thus, in squamous cell carcinoma of the lower lip, the mean of p53-positive cells is significantly increased (+41%) as compared to the other entities studied (p < 0.005).