Confundat adesea cu epiteliomul spinocelular, keratoacantomul isi pastreaza individualitatea clinica si histopatologica. In perioada 1969-1999 am diagnosticat 124 cazuri de keratoacantom. In majoritatea cazurilor, leziunile au fost unice; un caz a prezentat doua localizari la nivelul mainii, doua cazuri au prezentat o evolutie centrifuga; un caz cu localizare la nivelul vestibulului nazal si altul in zona sprancenei drepte au recidivat dupa excizie.

Examenul histopatologic a fost posibil in cazurile cu excizie in totalitate a tumorii, pe baza prezentei craterului central umplut de o masa masiva de tesut keratozic, inconjurat de o proliferare a epiteliului pluristratificat pavimentos, prezentand adesea aspecte asemanatoare cu cele ale epiteliomului spinocelular bine diferentiat. In 6 cazuri modificarile desmoplastice ale epiteliului proliferat au determinat aspecte pseudoglandulare.

Keratoacanthoma was frequently confused with squamous cell carcinoma but it has its own clinical and histopatological individuality. We diagnosed 124 keratoacanthomas in the 1969-1999 period. In the majority of cases, the tumors were solitar, in one case there were two tumors on the dorsum of the hand, two cases had a centrifugal evolution; we observed relapses in keratoacanthomas of the nasal vestibulum and one supraorbitar keratoacanthoma.

The diagnostic was based on histology of the in toto excised tumor. There was present a central crater filled with a huge mass of keratinized tissue, surrounded by a massive proliferation of the epidermal tissue resembling a well differentiated squamous cell epithelioma. Desmoplastic changes of the epithelial tissue caused a pseudoglandular aspect in 6 cases.